Synthetic Route of 851386-40-8, Adding some certain compound to certain chemical reactions, such as: 851386-40-8, name is 4-Chloro-2,5-difluoropyridine,molecular formula is C5H2ClF2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 851386-40-8.
[(00592] Step 1 : Preparation of (4-chloro-2,5-difluoropyridin-3-yl)(5-cyclopropylisoxazol-3-yl)methanone . A cold (-78 C) solution of 4-chloro-2,5-difluoropyridine (246 mg, 1.65 mmol) in THF (15.0 mL) was treated with 2.5 M n-BuLi in hexanes (718 pL, 1.79 mmol). After stirring for 2 h at -78 C, the reaction mixture was treated with a solution of methyl 5- cyclopropylisoxazole-3-carboxylate (250 mg, 1.50 mmol) in THF (2 mL). The resulting mixture was stirred overnight at ambient temperature before quenching with saturated NH4Q(aq). Subsequently, the mixture was diluted with water, and extracted with EtOAc. The organic extracts were washed with brine, dried over anhydrous Na2S04(S>, filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography (10-90% EtOAc in hexanes) to afford the title compound (201 mg, 47%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 851386-40-8, 4-Chloro-2,5-difluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRAY BIOPHARMA INC.; WALLS, Shane M.; REN, Li; RAMANN, Ginelle A.; MORENO, David A.; METCALF, Andrew T.; MCFADDIN, Elizabeth A.; KOLAKOWSKI, Gabrielle R.; BLAKE, James F.; DAI, Donghua; HAAS, Julia; JIANG, Yutong; KAHN, Dean; (368 pag.)WO2019/143994; (2019); A1;,
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