Adding a certain compound to certain chemical reactions, such as: 59942-87-9, Pyrazolo[1,5-a]pyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Pyrazolo[1,5-a]pyridin-2(1H)-one, blongs to pyridine-derivatives compound. Safety of Pyrazolo[1,5-a]pyridin-2(1H)-one
To a solution of 4a (3.10 g, 23.1 mmol) in THF (17 mL) and DMF (17mL) was added NaH (1.0 g, 25.4 mmol, 60% dispersion in oil) and Tf2NPh (9.90 g, 27.7 mmol) at 0 C. The mixture was stirred for 1 h, then it was added to ice-water and extracted with EtOAc. The organiclayer was washed with brine and dried (Na2SO4). The mixture was concentrated in vacuo. The crude material was purified by flash column chromatography (silica gel, hexane-EtOAc, 10:1) to give 3a as acolorless solid; yield: 6.10 g, 99%); mp 37-38 C.
The synthetic route of 59942-87-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Umei, Kentaro; Nishigaya, Yosuke; Kamiya, Megumi; Kohno, Yasushi; Seto, Shigeki; Synthesis; vol. 47; 20; (2015); p. 3221 – 3230;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem