In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine, the common compound, a new synthetic route is introduced below. Quality Control of 6-Bromo-3-chloro-2-methylpyridine
: 2-(tributylstannyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (2.69 g, 6.78 mmol), 6-bromo-3-chloro-2-methyl-pyridine (700.00 mg, 3.39 mmol), lithium chloride (287.43 mg, 6.78 mmol) and tetrakis(triphenylphosphine)palladium (391.77 mg, 339.00 mumol) were added to dioxane (30 mL). The reaction mixture was charged with nitrogen three times, then heated to 100-110 C and stirred for 12 h. The mixture was quenched by pouring into water (50 mL) and extracted with ethyl acetate (50 mL*3). The combined organic phases were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatograph (eluent: petroleum ether/ethyl acetate=10/1-5/1) to give 2-(5-chloro-6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b] pyrazole (600.00 mg, yield: 67.19%). 1H NMR (400MHz, CHLOROFORM-d) 7.65(q, J = 8.4 Hz, 2H), 6.59(s, 1H), 4.22(t, J = 7.2 Hz, 2H), 2.95(t, J = 7.3 Hz, 2H), 2.71-2.59(m, 5H).
The synthetic route of 944317-27-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Genfleet Therapeutics (Shanghai) Inc.; Medshine Discovery Inc.; SUN, Fei; WU, Lifang; DING, Charles Z.; HU, Guoping; LI, Jian; CHEN, Shuhui; LU, Jianyu; (45 pag.)EP3470409; (2019); A1;,
Pyridine – Wikipedia,
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