Electric Literature of 1033810-70-6 , The common heterocyclic compound, 1033810-70-6, name is [1,2,4]Triazolo[1,5-a]pyridin-7-ol, molecular formula is C6H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step F: Preparation of tert-butyl 4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-chloro-2-fluorobenzoate: A vial charged with tert-butyl 3-chloro-2,4-difluorobenzoate (0.210 g, 0.845 mmol), [1,2,4]triazolo[1,5-a]pyridin-7-ol (0.114 g, 0.845 mmol), cesium carbonate (0.413 g, 1.27 mmol), and DMF (1.7 ml). The reaction was heated to 80 C for 12 hours, then poured into ice water. The resulting solids were collected by filtration and purified by flash chromatography, eluting with gradient of 10% EtOAc/ Hexanes to 50% EtOAc/Hexanes to provide the desired product.
The synthetic route of 1033810-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Array Biopharma, Inc.; EP2090575; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem