With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65169-42-8, name is Methyl 6-chloro-5-methylnicotinate, molecular formula is C8H8ClNO2, molecular weight is 185.6076, as common compound, the synthetic route is as follows.Product Details of 65169-42-8
To a suspension of methyl 6-chloro-5-methyl-nicotinate (467 mg) in carbon tetrachloride (25 mL) were added N-bromosuccinimide (1.34 g) and benzoyl peroxide (218 mg), and the mixture was stirred at 100C for 7.5 hours. The mixture was cooled to room temperature, and to the reaction mixture were added saturated aqueous sodium thiosulfate solution and water, and the reaction mixture was extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtrated, and then concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (833 mg). LC-MS, condition B ([M+H]+/Rt (min)): 341.9/1.011
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65169-42-8, Methyl 6-chloro-5-methylnicotinate, and friends who are interested can also refer to it.
Reference:
Patent; Sumitomo Dainippon Pharma Co., Ltd.; FUKUNAGA, Yuichi; YAMAKAWA, Erina; SUGARU, Eiji; IKEDA, Satoshi; OTSUBO, Tsuguteru; UMEHARA, Hiroki; LI, Chiang Jia; (87 pag.)EP3560494; (2019); A1;,
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