Related Products of 52605-96-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 52605-96-6 as follows.
Example 32: N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3- {4- [6- (cyclopropylmethyl-amino)-5-methoxy-pyridin-3-yl]- [1, 2,3] triazol-1-yl}-4-methyl- benzamide; A mixture of 2.00 g (13.9 mmol) of 2-chloro-3-methoxypyridine (Lancaster) in 13.3 mL of aminomethylcyclopropane was heated at 125 C in a sealed tube for 4 days. The mixture was then cooled to room temperature and partitioned between Et20 and water. The aqueous layer was washed with Et2O, and the combined extracts were washed with brine, dried with MgS04, filtered, and concentrated. The residue was passed through a plug of silica gel with CHUCK to provide 1.25 g (7.01 mmol; 50%) of 2- cyclopropylmethylamino-3-methoxypyridine.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52605-96-6, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/90333; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem