New learning discoveries about 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,920966-03-6, 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid, and friends who are interested can also refer to it.

Related Products of 920966-03-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 920966-03-6, name is 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid. A new synthetic method of this compound is introduced below.

Preparation 59To a suspension of 4-chloro-lH-pyrrolo [2, 3-b]pyridine-5-Carboxylic acid (343 mg) in N,N-dimethylformamide (4 ml) was added phenylmethanol (375 mul) 4-dimethylaminopyridine (428 nig) and N- [3- (dimethylamino) propyl] -N’ -ethylcarbodiimide hydrochloride (676 mg) . After stirring at ambient temperature for 3 days, the reaction mixture was poured into water, and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4 and evaporated in vacuo. The residue was purified by column chromatography on silica gel with chloroform to give benzyl 4-chloro-lH-pyrrolo[2,3-b]pyridine-5-carboxylate (200 mg) as a yellow powder. 1H-NMR(DMSO-d6)OrS.40(2H,s) , 6.6 (IH, d, J=I.8Hz) , 7.35-7.39 (3H,m) , 7.41-7.45 (2H,m) ,7.71 (IH, d, J=3.5Hz) , 8.75 (IH, s) , 12.42 (IH, br) . EPO MS(ESI) :m/z 297.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,920966-03-6, 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; ASTELLAS PHARMA INC.; WO2007/7919; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem