As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
(b). 2,3-dimethoxypyridine To a solution of 2-chloro-3-methoxy-pyridine (1 10 g) in DMSO (1 L) was added sodium methoxide (124 g). The reaction mixture was heated to 80C overnight. The reaction mixture was poured into 3 L water and extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2S04, filtered and concentrated to give the crude product. Yield: 105 g ? NMR delta (ppm)(CH3OH-d): 7.70 (t, 1 H, J=1.2 and 5.2 Hz), 7.01 (t, 1 H, J=1.2 and 8.0 Hz), 6.81 (q, 1 H, J=5.2 and 7.8 Hz), 4.00 (s, 3H), 3.85 (s, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 52605-96-6.
Reference:
Patent; MSD OSS B.V.; BLACKABY, Wesley, Peter; DE KORT, Martin; ENTHOVEN, Mark; HINCHLIFFE, Paul, Stuart; PAULIE, Chris; TIMMERS, Cornelis, Marius; VERKAIK, Saskia; WO2013/41458; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem