Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1824-81-3, name is 2-Amino-6-picoline. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2
21.6 g of 2-amino-6-methylpyridine and 24 g of triethylamine were added to 200 ml of chloroform, and 26 g of pivaloyl chloride was added dropwise at 0C to the mixture. The obtained mixture was stirred at a room temperature for 1 day. Thereafter, a sodium bicarbonate aqueous solution was added to the reaction mixture, and it was then extracted with chloroform twice. The organic layer was dried over magnesium sulfate, and it was then concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography, so as to obtain 36.8 g of N-(6-methylpyridin-2-yl)-2,2-dimethylpropionic acid amide.N-(6-methylpyridin-2-yl)-2,2-dimethylpropionic acid amide [Show Image] 1H-NMR (CDCl3) delta: 1.33 (9H, s), 2.45 (3H, s), 6.88 (1H, d, J = 7.7 Hz), 7.58 (1H, dd, J = 8.1, 7.7 Hz), 7.94 (1H, br s), 8.05 (1H, d, J = 8.1 Hz).
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Reference:
Patent; Sumitomo Chemical Company, Limited; EP2248423; (2010); A1;,
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