In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5912-18-5, name is 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Safety of 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine
4,6-Dichloro-lH-pyrrolo[2,3-6]pyridine (1.0 g, 5.4 mmol) was combined with (R)-(+)-l -phenyl ethylamine (5.5 mL, 43 mmol) and the mixture was heated in the microwave reactor at 220 C for 4 hours. The mixture was cooled and washed three times with 10% aqueous citric acid, water, saturated NaCl, dried over Na2SC”4 and concentrated in vacuo. The dark residue was slurried in methylene chloride and the undissolved solids were removed by filtration, washed with methylene chloride then the filtrate was chromatographed on Si02 (Biotage SNAP 25g) and eluted with a gradient of ethyl acetate / hexanes. Two isomeric materials eluted from the column. The less polar material was confirmed as the desired product by NMR, (336 mg). LCMS ESI (+) m/z 272.1 (M+H).
The synthetic route of 5912-18-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PELOTON THERAPEUTICS, INC.; WANG, Bin; YANG, Hanbiao; BEDKE, Karl; WEHN, Paul; RIZZI, James P.; (241 pag.)WO2018/183635; (2018); A1;,
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