Synthetic Route of 1075-62-3 ,Some common heterocyclic compound, 1075-62-3, molecular formula is C7H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 25 mL round bottom flask, 5-(methoxymethylene)-2,2-dimethyl-i,3-dioxane- 4,6-dione (6.06 g, 32.5 mmol) was added to a stirred mixture of N-(6-aminopyridin-2- yl)acetamide (4.10 g, 27.1 mmol) in EtOH (5 ml) at room temperature. After the reaction mixture was stirred at 80C for 3 hr, it was cooled down to room temperature and then concentrated under vacuum to give the title compound as a solid. LCMS (ESI) calc?d for C,4H,5N305 [M+i ]: 306,found: 306; ?H NMR (300 MHz, CDC13): oei i.18(s, 1H), 9.27 (d, J= 4.2 Hz, 1H), 8.06 (d, J= 8.4 Hz, 1H), 7.90 (s,1H),7.77-7.72(m,1H), 6.73 (d, J= 7.8 Hz, 1H),2.26 (s,3H), 1.76 (s,6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
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