Synthetic Route of 18699-87-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18699-87-1, name is 2-Methyl-3-nitropyridine. A new synthetic method of this compound is introduced below.
EXAMPLE 2; 3-{4-[3-(2-Fluoro-5-trifluoromethylphenyl)-ureido]phenyl}-1H-pyrrolo[3,2-b]pyridine-2-carboxamide; Method b:; Ethyl 3-(3-nitropyridin-2-yl)-2-oxopropionate 121.7 g of ethyl oxalate and then 15.8 g of 2-methyl-3-nitropyridine in solution in 100 ml of ethanol are added to a solution of sodium ethanolate, prepared by adding 4 g of sodium to 400 ml of ethanol stirred under argon. The reaction mixture is stirred for 15 hours and the solid formed is filtered off, washed successively with 100 ml of ethanol and 100 ml of diisopropyl ether, and then filter-dried. The solid is taken up in 300 ml of ethanol and acidified with a 5N hydrochloric acid solution. The solid obtained is filtered off, washed with 50 ml of a 5N hydrochloric acid solution and then with 100 ml of ethanol, and filter-dried. After drying under vacuum, 18.7 g of ethyl 3-(3-nitro yridine-2-yl)-2-oxopropionate are obtained, the characteristics of which are as follows: MS (ES+) spectrum: m/z=239 [MH]+Melting point=38 C. (Koefler bench). 1H NMR spectrum (400 MHz, DMSO-d6, delta in ppm): 1.30 (t, J=7.0 Hz, 3H); 4.29 (q, J=7.0 Hz, 2H); 7.12 (s, 1H); 7.57 (dd, J=5.5 and 8.5 Hz, 1H); 8.66 (broad d, J=8.5 Hz, 1H); 8.85 (broad d, J=5.5 Hz, 1H); 14.9 (broad m, 1H). IR spectrum (KBr): 1722; 1644; 1560; 1532; 1346; 1231; 1141; 1024 and 777 cm-1
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18699-87-1, 2-Methyl-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; AVENTIS PHARMA S.A.; US2007/259910; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem