In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131747-62-1, name is 3-(Trifluoromethyl)pyridine-2-carboxaldehyde, the common compound, a new synthetic route is introduced below. Safety of 3-(Trifluoromethyl)pyridine-2-carboxaldehyde
N-((6- Azaspiro[2.5]octan-l-yi)methyl)-6-(2-chioro-5-fluorophenyi)pyridazm-3-aniine hydrochloride salt (11 mg, 0.028 mmol) was suspended in DCM (1 raL) and 3-(trifluoromethyl)pyridine-2- carbaldehyde (24 mg, 0.14 mmol) was added and allowed to stir at r.t. for 5 min, after which time sodium triacetoxyborohydride (30 mg, 0.14 mmol) was added. The resulting solution was stirred at r.t. overnight, after which time the reaction mixture was quenched with sat. NaHCO-j, and extracted with 3: 1 chloroform/IP A. Organic extracts were filtered through a phase separator, and concentrated. Crude residue was purified by RP-HPLC, and fractions containing product were basified with sat. NaHCQs, and extracted with 3: 1 chloroform/IP A. Organic extracts were filtered through a phase separator and concentrated to give the title compound as a colorless oil (6.2 mg, 44%). -WJR (400 MHz, CDCI3) delta 8.80 (dd, J= 4.6, 0.8 Hz, 1H), 7.95 (dd, J = 8.0, 1.2 Hz, 1H), 7,61 (d, ./ 9.3 Hz, I I I). 7,48 (dd, J = 9:2, 3, 1 Hz, 1H), 7,41 (dd, ,/ 8.8, 5,0 Hz, 1 1 1). 7.31 (dd, J= 7.8, 4.8 Hz, 1H), 7,07 – 7.02 (m, 1 1 1). 6.68 (d, J= 9.3 Hz, H i). 4.83 (t, ./ 4.6 Hz, 1H), 3,83 (s, 2H), 3,52 – 3.41 (m, 2H), 2,67 – 2.62 (m, 2H), 2.50 – 2,45 (m, 21 1). 1.83 – 1,78 (m, 1H), 1,69 – 1.65 (m, I I I). 1 ,49 – 1 ,46 (m, 1 1 1). 1.25 – 1 ,20 (m, H i). 1.05 – 0,97 (m, IH), 0.61 (dd, J= 8.4, 4.6 Hz, IH), 0,28 (t, ,/ 4,9 Hz, H i), ES-MS [M+H]+ = 506.2,
The synthetic route of 131747-62-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; BRIDGES, Thomas, M.; CONN, P., Jeffrey; BENDER, Aaron, M.; ENGERS, Darren, W.; (130 pag.)WO2019/14427; (2019); A1;,
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