Adding a certain compound to certain chemical reactions, such as: 15128-82-2, 2-Nitropyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 15128-82-2, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Nitropyridin-3-ol
300 g of TM2, 205 g of SM2 and 540 g of triphenylphosphine were dissolved in 2 L of THF and 361 g of DEAD was added dropwise at 0 C. After completion of the dropwise addition, the mixture was stirred at room temperature for two hours, and the reaction was complete by TLC (PE / EA = 3: 1).The ethyl acetate layer was dried and concentrated to 2 C to 0 C to precipitate a large amount of solid which was collected by filtration and the filtrate was concentrated to a final concentration of ethyl acetate. 1L. After cooling, the solid was separated. The solids were collected by filtration twice, washed with PE / EA = 5: 1 and filtered to remove solids (about 500 g), and the filtrate was evaporated to remove the solvent.Column chromatography gave 400 g of TM3 (pale yellow solid, eluent PE / EA = 7: 1) in 80% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15128-82-2, its application will become more common.
Reference:
Patent; JINAN TRIO PHARMATECH CO LTD; SUN, XUEYING; LI, JIE; LI, WANHU; GAO, YANFANG; YANFANG, KUN; (17 pag.)CN103664896; (2016); B;,
Pyridine – Wikipedia,
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