Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. A new synthetic method of this compound is introduced below., name: 2-Fluoro-3-(hydroxymethyl)pyridine
Dissolve (2-fluoropyridin-3-yl)methanol in 85 mL of dichloromethane.In ice bath for 10 minutes, 21.7 mL (306.04 mmol) of thionyl chloride was slowly added dropwise. The reaction solution changed from yellow to brown and the reaction was completed. The reaction was continued for 2 h with ice bath. The reaction was complete with TLC monitoring. Continue the ice bath for a while and slowly add 100 mL of water. The N2 was blown, and the lye was absorbed into the exhaust gas. The mixture was extracted with methylene chloride (100 mL*3), washed with saturated brine (100 mL), dried over anhydrous MgSO4, and evaporated under reduced pressure to give 7.14 g of a brown liquid, which was used as needed.
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Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
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