A new synthetic route of 2,6-Dichloro-3-nitropyridin-4-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2897-43-0, 2,6-Dichloro-3-nitropyridin-4-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2897-43-0, 2,6-Dichloro-3-nitropyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3Cl2N3O2, blongs to pyridine-derivatives compound. Computed Properties of C5H3Cl2N3O2

(6) 2,4,6-trichloro-3-nitropyridine 2,6-dichloro-3-nitropyridine-4-amine (2.27 g, 10.9 mmol) was added to 48 mL concentrated hydrochloric acid, and cooled to 0-5 C. To the solution was added sodium nitrite (2.26 g, 32.7 mmol) in batches. After the addition of sodium nitrite, the reaction solution was stirred for 1 h at 0-5 C., and then stirred for 2 h at 25 C., adjusted to pH=7 with 40% sodium hydroxide solution, and extracted with ethyl ether. After the organic phase was dried (Na2SO4) and concentrated, it was subjected to column chromatography eluted with petroleum ether to afford 2 g white solid with a yield of 80.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2897-43-0, 2,6-Dichloro-3-nitropyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; US2012/289497; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem