Related Products of 1849-52-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1849-52-1, name is 3-Methoxyisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.
Compound VI (23.8 g, 0.1 mol) was added to a 500 mL three-necked flask. Add tetrahydrofuran (100 mL), The stirring was started, and tetramethylpiperidine lithium (LTMP) (44 mL, 0.11 mol) was added dropwise at -40 ° C under nitrogen atmosphere. After the addition is completed, continue to stir for 0.5 hours. Then, a solution of 3-methoxy-4-pyridinecarboxaldehyde (13.7 g, 0.1 mol) in tetrahydrofuran was added dropwise. After the drop, continue to react at -40 ° C for 1 hour, TLC point plate monitoring,After the material point disappears, a saturated ammonium chloride solution is added dropwise below zero, and ethyl acetate is added. Extract, separate the organic layer, add anhydrous sodium sulfate to dry, filter,The filtrate was concentrated under reduced pressure.Obtained a yellow solid compound V-1, 32.9 g,The yield was 88percent.
According to the analysis of related databases, 1849-52-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Jin Yanjuan; (11 pag.)CN108689998; (2018); A;,
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