Synthetic Route of 851386-40-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.851386-40-8, name is 4-Chloro-2,5-difluoropyridine, molecular formula is C5H2ClF2N, molecular weight is 149.53, as common compound, the synthetic route is as follows.
To a microwave vial containing solution of 4-chloro-2,5-difluoropyridine (0.40 g, 2.7 mmol) in dioxane (7 mL), were added Intermediate 14C (1100 mg, 3.2 mmol), K3PO4 (1.30 g, 6.2 mmol), water (1.4 mL) and PdCl2(dppf)CH2Cl2 adduct (0.17 g, 0.21 mmol) at rt. The mixture was purged with nitrogen, and then was heated in a microwave reactor at 120 C for 6 min. The reaction mixture was cooled to rt. The aqueous layer was removed with a pipette. The organic phase was concentrated and was purified by normal phase chromatography to afford Intermediate 14D (350 mg, 47%) as a tan solid. LC-MS (ESI) m/z: 278.0 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 851386-40-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; QUAN, Mimi L.; HU, Zilun; WANG, Cailan; PATIL, Sharanabasappa; WO2015/2915; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem