Related Products of 1221171-70-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1221171-70-5, name is 2-Chloro-6-(trifluoromethoxy)pyridine, molecular formula is C6H3ClF3NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-chloro-6-(trifluoromethoxy)pyridine (5.0 g, 25.3 mmol, 1.0 equiv) in MeOH (120 mL) was added Pd(dppf)Cl2 (930 mg, 1.27 mmol, 0.05 equiv). The mixture was stirred at l00C under hydrogen atmosphere (50 Psi) for 48 hours. The reaction mixture was cooled to 20C and concentrated in vacuo. The residue was purified by silica gel chromatography (PE/EA = 10/1) to afford the title compound methyl 6- (trifluoromethoxy)picolinate as yellow oil (3.85 g, 68% yield). LC-MS: m/z 222.0 (M+H) +
According to the analysis of related databases, 1221171-70-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ANNAPURNA BIO, INC.; TANG, Haifeng; HANSON, Michael; BOYCE, Sarah; NIE, Zhe; (461 pag.)WO2020/73011; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem