As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62674-71-9, name is 2-Iodo-6-methylpyridine, molecular formula is C6H6IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Iodo-6-methylpyridine
A mixture of Compound la (55 mg, 0.171 mmol) 2-bromo-6-methylpyridine (23.4 ul, 0.205 mmol), tetrakis(triphenylphosphine)palladium (7.89 mg, 0.007 mmol), sodium acetate (28 mg, 0.342 mmol) and tetrabutylammonium fluoride (44.7 mg, 0.17 1 mmol)) in anhydrous DMF (3 mL) was heated at 110°C into a microwave oven (Biotage Smith Creator®) for 10 mm then cooled at r.t.. The reaction mixture was poured into water and extracted with EtOAc (3x). The organic layer was dried over Na2504 and the solvent was evaporated to dryness to give a crude which was purified via automated flashchromatography (SP1® Biotage, SNAP25 Cartridge), eluting with a EtOAc – PetroleumEther gradient from 75:25 to 1:1 to give mg 51(87.6percent) of the title compound.UPLC-MS [M+H]= 341.521H NMR (400 MHz, DMSO-d6) oe ppm 7.68 (t, 1 H), 7.31 (d, 1 H), 7.22 (d, 1 H), 5.66 (s,1 H), 3.43 (brt, 2 H), 3.15 (s, 2 H), 2.62 (brt, 2 H), 2.45 (s, 3 H), 1.42 (s, 9 H), 1.08 (s, 6H)
With the rapid development of chemical substances, we look forward to future research findings about 62674-71-9.
Reference:
Patent; RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA; RIVA, Carlo; GRAZIANI, Davide; LONGHI, Matteo; CALLEGARI, Elisa; FRIGERIO, Fabio; ANGELICO, Patrizia; (197 pag.)WO2019/2571; (2019); A1;,
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