Synthetic Route of 16744-81-3, Adding some certain compound to certain chemical reactions, such as: 16744-81-3, name is 4-Methoxypicolinaldehyde,molecular formula is C7H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16744-81-3.
General procedure: A mixture of 6-(3 -hydroxypropoxy)-4-(6-(piperazin- 1 -yl)pyridin-3 -yl)pyrazolo[ 1,5 -a]pyridine-3 -carbonitrile hydrochloride (Intermediate P51; 12.1 mg, 0.0292mmol), 5-chloropicolinaldehyde (8.26 mg, 0.0583 mmol) and NaBH(AcO)3 (18.5 mg, 0.0875mmol) in DCE (583 tL) was stirred for 1 day at ambient temperature. The mixture was purified directly by C18 reverse phase (5-95percent ACN/ water with 0.1percent TFA as the gradient eluent) to afford the title compound (17.1 mg, 95percent yield). MS (apci) m/z = 504.2 (M+H).
According to the analysis of related databases, 16744-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; TANG, Tony P.; REN, Li; (668 pag.)WO2018/71447; (2018); A1;,
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