Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 327056-62-2, name is 2-Cyano-5-fluoropyridine. A new synthetic method of this compound is introduced below., name: 2-Cyano-5-fluoropyridine
The mixture of 5-fluoro-pyridine-2-carbonitrile (0.16 g, 1.27 mmol) and Pd/C (0.030 g, 10% wt) in 15 ml of MeOH and 0.50 ml of concentrated HCl was placed under H2 which was provided by a balloon and stirred at RT for 4 h, filtered through Celite, condensed, the residue was purified by flash column chromatography. The titled compound was obtained as a light yellowish solid. MS (ES+): 127.2 (free base)(M+H)+. Calc’d for C6H7FN2 (free base) 126.13.
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Reference:
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
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