Application of 32710-65-9 ,Some common heterocyclic compound, 32710-65-9, molecular formula is C6H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 61Mol Weight: 218.70[00616] Synthesis of Intermediate (1)Molecular Weig ht: 173.00 Molecular Weight: 168.58[00617] In a 25-mL,3Nround-bottomed flask equipped with thermometer pocket fitted with a nitrogen inlet and a rubber septum, NaH (0.1 12 g, 1.0 eq.), methanol (0.1 1 mL, 1.0 eq.), suspended in N-Methyl pyrolidine (5 niL). The reaction mixture was stirred at 25-30C for 30 min. To this reaction mixture 2, 6-Dichloro,4-cyano-pyridine was added at 0-5 C. The progress of the reaction was followed by TLC analysis on silica gel with 10%EtOAc- hexane as mobile phase which shows completion after 2 h staring at 0-5 C. Reaction was quenched by water and precipitate was observed which was filtered and wash with hexane to give required compound (0.51 g, Crude). Reaction was stirred for 20 min with water and solid was separated and compound was collected by filtration and washed with hexane (30mL).Yield:0.51 g Crude.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32710-65-9, its application will become more common.
Reference:
Patent; KARYOPHARM THERAPEUTICS, INC.; SHECHTER, Sharon; KAUFFMAN, Michael; SANDANYAKA, Vincent, P.; SHACHAM, Sharon; WO2011/109799; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem