The origin of a common compound about 885168-04-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 885168-04-7, 5-Bromo-3-chloropicolinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3BrClNO, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3BrClNO

5-Bromo-3-chloropicolylaldehyde 2.06 gAnd 1.00 g of 1-butylamineIn 10 ml of toluene,While performing azeotropic dehydration using a Dean-Stark tube,It was heated to reflux for 2 hours.Then,The solvent was distilled off under reduced pressure,To the residue was added acetic acid 10 mlAnd 1.05 g of nitroethane were added,Followed by stirring at 100 C. for 40 minutes.After completion of the reaction,The reaction mixture was allowed to cool to room temperature, 30 ml of water was added, and the mixture was extracted with ethyl acetate (50 ml × 2).The organic layers were combined, dried over anhydrous sodium sulfate and then saturated brine, dried,The solvent was distilled off under reduced pressure,The residue was purified by silica gel column chromatography eluting with ethyl acetate-hexane (3: 97)0.76 g of the objective compound was obtained as brown crystals.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885168-04-7, 5-Bromo-3-chloropicolinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; nissan chemical industries, Ltd.; Takeshi, Mita; Yuki, Tajima; Yusuke, Nanya; Kosay, Iwasa; Makoto, Inada; Miho, Asahi; (124 pag.)JP2017/39722; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem