Electric Literature of 881-86-7 ,Some common heterocyclic compound, 881-86-7, molecular formula is C9H9NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1. Preparation of (c^)-dimethyl piperidine-2.5-dicarboxylate To dimethyl pyridine-2,5-dicarboxylate (50 g) was added AcOH (500 mL) and catalyst 5percent RI1/AI2O3 (5 g). The reaction mixture was shaked under H2 (100 psi) at 25 oC for 16 h. The catalyst was removed by filtartion. The AcOH was removed under vacuum and the residue was used without furtherpuirification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,881-86-7, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph, A.; ALHASSAN, Abdul-Basit; ANAND, Rajan; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; YU, Wensheng; YU, Younong; LIU, Shilan; WU, Hao; YANG, Chundao; (120 pag.)WO2016/109215; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem