Analyzing the synthesis route of 5350-93-6

According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.

Application of 5350-93-6, Adding some certain compound to certain chemical reactions, such as: 5350-93-6, name is 6-Chloropyridin-3-amine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5350-93-6.

To a solution of 3-amino-6-chloropyridine (lOOmg, 0.77mmol) in DCM (3mL) at -78¡ãC was added a solution of tBuOCl (leq, 87muL) in DCM (ImL) via cannula. After 10 min, a solution of thiomethylacetone (leq, 80 uL) in DCM (ImL) was added via cannula. The reaction stirred for 90 min before the addition of a solution OfNEt3 (leq, 108uL) in DCM (ImL). The mixture was warmed to 25¡ãC. After 2 h, the reaction was quenched with water and extracted with DCM (2x). The organic layer was dried over Na2SO4 and concentrated. Purification via flash chromatography eluding with a gradient of 0 to 100percent EtOAc/hexanes provided 5-chloro-2- methyl-3-(methylthio)-lH-pyrrolo[3,2-b]pyridine as a tan solid.1H NMR (500 MHz, CDCl3): delta 6.89 (bs, IH), 7.51 (d, IH), 7.08 (d, IH), 2.59 (s, 3H), 2.36 (s,3H).

According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2009/5672; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem