In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153813-70-8, name is 3-Nitroisonicotinaldehyde, the common compound, a new synthetic route is introduced below. SDS of cas: 153813-70-8
A mixture of 3-nitropyridine-4-carboxaldehyde (1.50 g, 9.86 mmol), N-Boc-piperidine-3,5-dione (2.52 g, 11.83 mmol) and iron (2.75 g, 49.3 mmol) in acetic acid (50 mL) was heated at 50C for 3h. The mixture was concentrated in vacuo. The solution was co-evaporated twice with toluene. The residue was dissolved in AcOEt and a saturated solution of NaHCO3. The mixture was filtered over celite. The layers of the filtrate was separated. The aqueous layer was extracted with AcOEt. The organic layers were combined, dried over Na2SO4, filtered and concentrated in vacuo. Acetone (20 mL) was added to the residue and the mixture refluxed for 30min. The mixture was cooled at rt and filtrated to provide intermediate ( 5a) as an off-white solid (1.21 g, 4.01 mmol, 40%). MS m/z ([M+H]+) 302. 1H NMR (400 MHz, DMSO-d6): delta (ppm) 1.43 (s, 9H), 3.55 (s, 2H), 3.94 (s, 2H), 4.29 (s, 2H), 7.13 (d, J = 4.9 Hz, 1H), 7.91-8.19 (m, 2H), 9.76 (s, 1H).
The synthetic route of 153813-70-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mutabilis; BARBION, Julien; CARAVANO, Audrey; CHASSET, Sophie; CHEVREUIL, Francis; LECOINTE, Nicolas; LE STRAT, Frederic; OLIVEIRA, Chrystelle; SIMON, Christophe; (44 pag.)EP3604309; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem