Electric Literature of 56673-34-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56673-34-8, name is 3-Bromo-6-mercaptopyridine. This compound has unique chemical properties. The synthetic route is as follows.
To MeOH (40 mL) cooled to 0 C with an ice-bath, was added sodium hydride (60% in mineral oil) in portions. The cooling bath was removed and the mixture was stirred at rt for 15 min. 5-bromopyridine-2-thiol (l.Og, 5.3 mmol) was added in one portion and the reaction mixture stirred at rt for 15 min until the solid dissolved. diethyl 2-chloromalonate was added dropwise, and the reaction mixture was stirred at rt for 2 hr. MeOH was removed under reduced pressure and the reaction mixture was diluted with diethyl ether and quenched by the addition of 1.0 N HC1. The resulting mixture was partitioned between water/diethyl ether. The organic layer was collected, washed with brine and dried over sodium sulfate. The residue was purified by flash chromatography (loading in chloroform, 0% to 30% EtOAc in hexane over 18 min using a 120 g silica gel cartridge). The desired fractions were combined and concentrated under reduced pressure to yield 98a (1.3 g, 71% yield) as a clear oil. LCMS (Method M) retention time = 0.96 min, m/z = 349.8 (M+H)+. NMR (500MHz, chloroFORM-d) 8.47 (dd, J=2.3, 0.7 Hz, IH), 7.66 (dd, J=8.5, 2.5 Hz, IH), 7.17 (dd, J=8.5, 0.8 Hz, IH), 4.29 (q, J=7.2 Hz, 4H), 1.31 (t, J=7.2 Hz, 6H)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56673-34-8, 3-Bromo-6-mercaptopyridine.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; TORA, George, O.; FINLAY, Heather; JIANG, Wen; MENG, Wei; ZHANG, Xiaojun; (303 pag.)WO2017/218633; (2017); A1;,
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