Related Products of 60010-03-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60010-03-9 as follows.
c) 4-Methyl-3-nitropyridine-2,6-diamine (A 100) To 2,6-dichloro-4-methyl-3-nitropyridine A99 (100 mg, 0.483 mmol) was added 29% w/w aqueous ammonia (1.0 mL, 16 mmol). The mixture was irradiated in a microwave reactor at 130 C for 30 minutes. The mixture was cooled, diluted with water (1.0 mL) and the precipitate filtered to give a brown solid. The solid was purified by silica gel chromatography (12 g silica cartridge, 0-100% EtOAc in petroleum benzine 40-60 C) to give the title compound (0.035 g, 43%) as a yellow solid. H NMR (400 MHz, cf6-DMSO): delta 7.64 (br s, 2H), 6.97 (brs, 2H), 5.74 (d, J = 1.0 Hz, 1 H), 2.39 (d, J = 0.9 Hz, 3H). LC-MS: rt 2.67 min, m/z (positive ion) 168.2 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60010-03-9, its application will become more common.
Reference:
Patent; CANCER THERAPEUTICS CRC PTY LTD; STUPPLE, Paul Anthony; WALKER, Scott Raymond; PINSON, Jo-Anne; LAGIAKOS, Helen Rachel; LUNNISS, Gillian Elizabeth; HOLMES, Ian Peter; STUPPLE, Alexandra Elizabeth; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; KERSTEN, Wilhelmus Johannes Antonius; CAMERINO, Michelle Ang; WO2014/128465; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem