Electric Literature of 60032-57-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60032-57-7, name is 2-Methylnicotinaldehyde, molecular formula is C7H7NO, molecular weight is 121.14, as common compound, the synthetic route is as follows.
[00348] To a solution of 2-methyl -pyridine 3-carbaldehyde (14) (0.5 g, 4.1 mmol) in pyridine (2.5 mL) was added malonic acid (0.65g, 6.1 mmol) and catalytic piperidine (0.2 mL). The reaction mixture was refluxed at 100 C for 3 h and then concentrated under reduced pressure. The residue was diluted with water and the solid product was filtered to give fE)-3-(2-methylpyridin-3-yl) acrylic acid 15. Yield (0.47 g, 71 %). 1H MR (400 MHz, DMSO-< Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem