In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14667-47-1, name is Methyl 2-aminonicotinate, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H8N2O2
To a stirred solution of methyl 2-aminonicotinate (1.3 g, 8.54 mmol) and methyl propionate (20.08 mL, 214 mmol) in THF (20 mL) was added sodium 2-methyl- propan-2-olate (2.053 g, 21.36 mmol) portionwise over 1 min. The reaction was stirred at rt for 40 min and at 100 C for 4 h. After this time the reaction was cooled to rt and evaporated in vacuo. The resulting solid was dissolved in water (20 mL) and neutralized to pH 7 with 1.0M aqueous HCl. The resulting solid was filtered and dried under vacuum overnight to give 3 -methyl- 1,8 -naphthyrid- ine-2,4-diol as a tan solid. Mass Spectrum (ESI) m/e = 177.2 (M + 1).
The synthetic route of 14667-47-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Yi; CUSHING, Timothy D.; GONZALEZ LOPEZ DE TURISO, Felix; HE, Xiao; KOHN, Todd J.; LOHMAN, Julia Winslow; PATTAROPONG, Vatee; SEGANISH, Jennifer; SHIN, Youngsook; SIMARD, Jillian L.; WO2010/151737; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem