Application of 55314-16-4 ,Some common heterocyclic compound, 55314-16-4, molecular formula is C10H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
176 g (1.00 mol) of starting material III and 121.6 g (1.10 mol) of starting material IV hydrochloride salt wherein R is methyl was added to a solution of 44 g (1.1 mol) of sodium hydroxide in 1000 ml of methanol then stirred and dissolved. The reaction was heated at reflux for 8 hours. The reaction temperature was 65C. After completion of the reaction, the mixture was decolorized at 50C under reduced pressure (i.e., the solvent was removed, the same applies hereinafter). 400 ml of dichloromethane and 400 ml of pure water were further added to dissolve and stir and extract the liquid. The organic layer was washed once more with 400 ml of pure water. 50 g of anhydrous sodium sulfate for 1 hour. Filtered. Solvent was removed to obtain 173.7 g of a pale yellow oil 2-methoxy-4-(3-pyridyl)pyrimidine. The molar yield was 92.8%. HPLC purity 98.72%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55314-16-4, 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Peking University Founder Group Co., Ltd.; Southwest Synthetic Pharmaceutical Co., Ltd. of PKU International Healthcare Group Co., Ltd.; PKU Care Pharmaceutical R&D Center Co., Ltd.; PKU Healthcare Industry Group; Xu, Hong; Zhang, Zheng; Wang, Wei; (13 pag.)CN104230885; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem