Wu, Huizhen;Zhou, Min;Xu, Jie;Wang, Jianmei;Tong, Jianying;Sun, Nabo;Qian, Mingrong published 《Determining a wide range of antibiotics and pesticides in poultry feathers using selective accelerated solvent extraction-liquid chromatography-mass spectrometry》. The research results were published in《Analytical Methods》 in 2022.Category: pyridine-derivatives The article conveys some information:
This study established a detection method based on accelerated solvent extraction-liquid chromatog.-mass spectrometry for determining residues of 3 chloramphenicols, 8 macrolides, 18 sulfonamides, 4 nitroimidazoles, 15 insecticides, and 22 fungicides in poultry feathers. The extraction solvent, methanol, was used for a static extraction time of 5 min, and repeated three times. Fifty milligrams of adsorbents C18/PSA (1 : 1, W/W) were added to the extraction cell to achieve simultaneous extraction and purification The extraction efficiency of three solvents, methanol, acetonitrile and Et acetate, was investigated. An orthogonal exptl. design was used to explore the optimal combination of extraction temperature, static extraction time, number of extraction cycles, and adsorbent ratio for accelerated solvent extraction After the optimal ratio was determined, the dosage of adsorbents was optimized. The extracted sample solution was concentrated by blowing nitrogen, redissolved, passed through a 0.22 μm PTFE membrane filter, then injected for instrumental anal. The validation results showed that the recovery of the proposed method was 60.4-107.6%, the limit of detection 0.2-3.0 μg kg-1, and the limit of quantification 0.5-8.3 μg kg-1. This quant. multi-residue detection method was able to determine the residues of 70 target compounds in poultry feathers.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.
4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.