Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. HPLC of Formula: 5315-25-3.
Cherney, Emily C.;Zhang, Liping;Guo, Weiwei;Huang, Audris;Williams, David;Seitz, Steven;Shan, Weifang;Zhu, Xiao;Gullo-Brown, Johnni;Maley, Derrick;Lin, Tai-an;Hunt, John T.;Huang, Christine;Yang, Zheng;D’Arienzo, Celia J.;Discenza, Lorell N.;Ranasinghe, Asoka;Grubb, Mary F.;Traeger, Sarah C.;Li, Xin;Johnston, Kathy A.;Kopcho, Lisa;Fereshteh, Mark;Foster, Kimberly A.;Stefanski, Kevin;Delpy, Diane;Dhar, Gopal;Anandam, Aravind;Mahankali, Sandeep;Padmanabhan, Shweta;Rajanna, Prabhakar;Murali, Venkata;Mariappan, T. Thanga;Pattasseri, Shabeerali;Nimje, Roshan Y.;Hong, Zhenqiu;Kempson, James;Rampulla, Richard;Mathur, Arvind;Gupta, Anuradha;Borzilleri, Robert;Vite, Gregory;Balog, Aaron research published 《 Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors》, the research content is summarized as follows. IDO1 inhibitors have shown promise as immunotherapies for the treatment of a variety of cancers, including metastatic melanoma and renal cell carcinoma. We recently reported the identification of several novel heme-displacing IDO1 inhibitors, including the clin. mols. linrodostat (BMS-986205) and BMS-986242. Both mols. contain quinolines that, while being present in successful medicines, are known to be potentially susceptible to oxidative metabolism Efforts to swap this quinoline with an alternative aromatic system led to the discovery of 2,3-disubstituted pyridines as suitable replacements. Further optimization, which included lowering ClogP in combination with strategic fluorine incorporation, led to the discovery of compound 29 (I), a potent, selective IDO1 inhibitor with robust pharmacodynamic activity in a mouse xenograft model.
HPLC of Formula: 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.