Reference of 799293-83-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 799293-83-7 as follows.
3-Bromothieno[3,2-c]pyridin-4(5H)-one (1.09 g, 4.74 mmol) synthesized according to a known method (WO2004/100947) was suspended in DMF (24 mL), and potassium carbonate (1.96 g, 14.2 mmol) and methyl 4-toluenesulfonate (0.858 mL, 5.68 mmol) were added. The mixture was stirred overnight at room temperature. After adding a saturated sodium bicarbonate aqueous solution to the reaction mixture, the insoluble matter was filtered, and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was washed with diethyl ether to give Compound bc (670 mg, 58 %). ESI-MS: m/z 244 [M + H]+. 1H-NMR (CDCl3) delta (ppm): 7.23 (s, 1H), 7.19 (d, J = 7.8 Hz, 1H), 6.62 (d, J = 7.8 Hz, 1H), 3.60 (s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-83-7, its application will become more common.
Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; OTSUBO, Nobumasa; OKAZAKI, Shuko; TSUKUMO, Yukihito; IIDA, Kyoichiro; NAKOJI, Masayoshi; EP2708540; (2014); A1;,
Pyridine – Wikipedia,
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