Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Related Products of 766-11-0.
Dransfield, Paul J.;Pattaropong, Vatee;Lai, Sujen;Fu, Zice;Kohn, Todd J.;Du, Xiaohui;Cheng, Alan;Xiong, Yumei;Komorowski, Renee;Jin, Lixia;Conn, Marion;Tien, Eric;DeWolf, Walter E.;Hinklin, Ronald J.;Aicher, Thomas D.;Kraser, Christopher F.;Boyd, Steven A.;Voegtli, Walter C.;Condroski, Kevin R.;Veniant-Ellison, Murielle;Medina, Julio C.;Houze, Jonathan;Coward, Peter research published 《 Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394》, the research content is summarized as follows. Glucokinase (GK) catalyzes the phosphorylation of glucose to glucose-6-phosphate. We present the structure-activity relationships leading to the discovery of AM-2394, a structurally distinct GKA. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approx. 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
Related Products of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.