Adding a certain compound to certain chemical reactions, such as: 796851-03-1, 2,5-Dichloro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,5-Dichloro-4-iodopyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2,5-Dichloro-4-iodopyridine
a) A mixture of 2,5-dichloro-4-iodopyridine (0.2 g, 0.73 mmol), 7-amino-2-methyl- 3H-isoindol-l-one (0.118 g, 0.73 mmol), palladium(II) acetate (6.56 mg, 0.03 mmol), 9,9- dimethyl-4,5-bis(diphenylphosphino)xanthene (0.025 g, 0.04 mmol) and cesium carbonate (0.476 g, 1.46 mmol) were suspended in dioxane (5 mL). The mixture was heated at 1000C for 30 minutes in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution OfNH3 in MeOH. Fractions containing product were combined and evaporated. A solid recovered from the top of the column was washed with water, dried in vacuo, and combined with the evaporated residue to afford 7-[(2,5-dichloropyridin-4- yl)amino]-2-methyl-3H-isoindol-l-one (0.160 g, 71% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 3.07 (3H, s), 4.50 (2H, s), 7.25 – 7.28 (IH, m), 7.48 (IH, s), 7.56 – 7.63 (2H, m), 8.36 (IH, s), 9.80 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 308.01 and 309.97 and 311.99.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,796851-03-1, 2,5-Dichloro-4-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem