Synthetic Route of 624734-22-1 ,Some common heterocyclic compound, 624734-22-1, molecular formula is C7H2ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step D 1-methyl-5-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine A solution of 2-chloro-5-(trifluoromethyl)nicotinonitrile (as prepared in the previous step, 342 mg, 1.65 mmol) in ethanol (10 mL) in a 50-mL round-bottom flask, was treated with MeNH2NH2 (100 L, 2.05 mmol). The reaction mixture was stirred overnight at 90 C. The resulting mixture was concentrated under vacuum. The residue was purified by chromatography over a silica gel column with dichloromethane/ethylacetate (1:1), to give the title compound as a yellow solid. 1H NMR(CHLOROFORM-d) delta: 8.69 (d, J=1.5 Hz, 1H), 8.15 (s, 1H), 4.24 (br. s., 2H), 3.97 (s, 3H); LC-MS (ES, m/z) 217[M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624734-22-1, 2-Chloro-5-(trifluoromethyl)nicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhang, Xuqing; Sui, Zhihua; Lanter, James C.; US2011/306592; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem