Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. HPLC of Formula: 766-11-0.
Engers, Julie L.;Rodriguez, Alice L.;Konkol, Leah C.;Morrison, Ryan D.;Thompson, Analisa D.;Byers, Frank W.;Blobaum, Anna L.;Chang, Sichen;Venable, Daryl F.;Loch, Matthew T.;Niswender, Colleen M.;Daniels, J. Scott;Jones, Carrie K.;Conn, P. Jeffrey;Lindsley, Craig W.;Emmitte, Kyle A. research published 《 Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents》, the research content is summarized as follows. Previous preclin. work has demonstrated the therapeutic potential of antagonists of the group II metabotropic glutamate receptors (mGlus). Still, compounds that are selective for the individual group II mGlus (mGlu2 and mGlu3) have been scarce. There remains a need for such compounds with the balance of properties suitable for convenient use in a wide array of rodent behavioral studies. The authors describe here the discovery of a selective mGlu3 NAM I (VU0650786) suitable for in vivo work. Compound I is a member of a series of 5-aryl-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one compounds originally identified as a mGlu5 pos. allosteric modulator (PAM) chemotype. Its suitability for use in rodent behavioral models has been established by extensive in vivo PK studies, and the behavioral experiments presented here with compound I represent the first examples in which an mGlu3 NAM has demonstrated efficacy in models where prior efficacy had previously been noted with nonselective group II antagonists.
HPLC of Formula: 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.