At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Recommanded Product: Pyridine-3-sulfonyl chloride.
Guzelj, Samo;Gobec, Martina;Urbancic, Dunja;Mlinaric-Rascan, Irena;Corsini, Emanuela;Jakopin, Ziga research published 《 Structural features and functional activities of benzimidazoles as NOD2 antagonists》, the research content is summarized as follows. To gain insight into the structure-activity relationships of NOD2 antagonists, a series of novel analogs was designed and synthesized, and then screened for antagonist activity vs. NOD2, and counter-screened vs. NOD1. N-(2,3-Dihydro-1H-indene-5-yl)-2-(2-(2-(phenylsulfonamido)ethyl)-1H-benzo [d]imidazole-l-yl)acetamide and N-(2,3-dihydro-1H-indene-5-yl)-2-(2-(2-(phenylsulfonamido)ethyl)-1H-benzo [d]imidazole-l-yl)acetamide were identified as potent and moderately selective NOD2 antagonists, and N-(2,3-dihydro-1H-indene-5-yl)-2-(2-(2-((5-(dimethylamino)naphthalene)-1-sulfonamido)ethyl)-1H-benzo[d]imidazole-1-yl)acetamide and N-(2,3-dihydro-1H-inden-5-yl)-2-(2-(3-(Nmethylphenylsulfonamido)propyl)-1H-benzo[d]imidazol-1-yl)acetamide as dual NOD1/NOD2 antagonists, with balanced activities against both targets in the low micromolar range. These data enable in-depth exploration of their structure-activity relationships and provide deeper understanding of the structural features required for NOD2 antagonism.
Recommanded Product: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.