Shahriman, Mohamad Shariff;Mohamad, Sharifah;Mohamad Zain, Nur Nadhirah;Alias, Yatimah;Chandrasekaram, Kumuthini;Raoov, Muggundha published 《Paper-based polymeric ionic liquid for thin film micro extraction of sulfonamides in environmental water samples prior to HPLC-DAD analysis》. The research results were published in《Microchemical Journal》 in 2021.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:
Paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) was successfully developed by grafting the polymeric ionic liquid on the surface of com. filter paper by using dipping method, presenting a new cost-effective film. The newly developed p-Poly-(MMA-IL) was then applied as a paper-based thin film microextraction (p-TFME) to extract four representative sulfonamides (SAs) drugs, which were sulfadiazine, sulfachloropyridazine, sulfamethoxazole, and sulfadimethoxine in environmental water samples. Besides, p-Poly-(MMA-IL) was successfully characterised by FTIR, FESEM, and XRD techniques and underwent significant parameters optimization, which affected the extraction efficiency. Under optimal conditions, the proposed method (p-Poly-(MMA-IL)-TFME) was evaluated and applied to analyze SAs in environmental water samples by using a high-performance liquid chromatog.-diode array detector (HPLC-DAD). The validation method showed that a good linearity (0.50 μg L-1 -500 μg L-1) was noted (R2 > 0.999, n = 3). Detection and quantification limits were within 0.14 μg L-1 – 0.52 μg L-1 and 0.41 – 1.57 μg L-1, resp., the preconcentraction factors were > 14.95, and the matrix effect was less than 2.64%, an acceptable percentage for real samples anal. The extraction recoveries of environmental water samples were ranged from 90.4% to 109.9% with a relative standard deviation (RSD) of less than 9.8%. The newly developed paper-based polymeric ionic liquid p-Poly-(MMA-IL) for anal. of SAs under the p-TFME procedure was successfully achieved with limited sample volume and organic solvent, fast extraction, and practicable in the daily anal. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .
4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.