Today I want to share an article with you. The article is 《Transition-Metal-Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines》,you can find this article in 《Advanced Synthesis & Catalysis》. The following contents are mentioned:
This study reports the invention of di- or trifunctionalization of readily available pyridines (including all the pyridine substrates utilized in this paper, such as 3-cyanopyridine and 3-chloropyridine) through dearomative functionalization-oxidative rearomatization under transition-metal- and reductant-free conditions. Although a two-step operation is required, the crude product of the first step could be used in the next step directly. Typically, 3-π-EWG pyridines underwent difunctionalization, whereas 3-σ-EWG pyridines participate in trifunctionalization, affording multisubstituted piperidines. Computational studies provide detailed insights for their distinct reactivity in the title reaction. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2