Quality Control of 3-CyanopyridineIn 2021, Wasfy, Nour;Doan, Brian;Rasheed, Faizan;Fishlock, Dan;Orellana, Arturo published 《Palladium-Catalyzed, Mild Dehydrogenation of 4-Alkylpyridines》. 《ACS Catalysis》published the findings. The article contains the following contents:
A mild palladium-catalyzed selective dehydrogenation of 4-alkylpyridines e.g., I that exploits their soft enolization to alkylidene dihydropyridines e.g., II using allyl chloroformate under metal-free conditions was reported. Treatment of these intermediates with a palladium catalyst liberates an alkylpyridylic anion and an allylpalladium(II) intermediate, which combine and undergo β-hydride elimination to install a double bond. Importantly, the formation of gas byproducts makes the process very practical. Furthermore, the reaction tolerates a broad range of functional groups, including many that can be dehydrogenated using similar palladium-catalyzed reactions, and is selective for 4-alkylpyridines e.g., I even in substrates bearing multiple pyridylic positions. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine