Xu, Xu;Zhao, Wenhao;Ji, Baocheng;Han, Yu;Xu, Gaigai;Jie, Mingsha;Wu, Nan;Wu, Yongmei;Li, Junguang;Li, Ke;Zhao, Dianbo;Bai, Yanhong published 《Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS》. The research results were published in《Food Chemistry》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:
Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%∼97.0%, relative standard deviation (RSD) ≤ 10.8%), and linearities (R2 ≥ 0.999), as well as low limits of quantitation (0.3 ∼ 10.9μg·kg-1) and detection (0.1 ∼ 3.8μg·kg-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0μg·kg-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .
4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.