Reference of 1427-06-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1427-06-1 as follows.
General procedure: A mixture of substituted piperazine, homopiperazine or piperidine (X), methyl 4-fluorobenzoate and K2CO3 in DMSO was refluxed at 120 C for 24 hrs resulting in the formation of an off-white precipitate. The reaction mixture was cooled to room temperature and then poured into a vessel containing water. The mixture was left to stir at room temperature for 30 minutes and the solid was collected via filtration, washed with water and air dried overnight to give the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1427-06-1, its application will become more common.
Reference:
Article; Jalily, Pouria H.; Eldstrom, Jodene; Miller, Scott C.; Kwan, Daniel C.; Tai, Sheldon S.-H.; Chou, Doug; Niikura, Masahiro; Tietjen, Ian; Fedida, David; Molecular Pharmacology; vol. 90; 2; (2016); p. 80 – 95;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem