Name: (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole《Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction》 was published in 2019. The authors were Lux, Michaelyn C.;Boby, Melissa L.;Brooks, Joshua L.;Tan, Derek S., and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:
Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.(R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1835671-08-3) were involved in the experimental procedure.
N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.