Fan, Weibin;Zhang, Yuan;Li, Yinghua;Zhang, Wei;Huang, Deguang published 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》 in 2022. The article was appeared in 《ChemSusChem》. They have made some progress in their research.Quality Control of 3-Cyanopyridine The article mentions the following:
A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine