Reference of 1034467-80-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine, molecular formula is C8H8FN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a reaction vial designed for microwave heating, 3-cyclopropyl-4-phenoxy-l H- pyrazole (0.16 g, 0.799 mmol), 5-cyclopropyl-2-fluoropyridine (intermediate 50) (0.11 g, 0.799 mmol) and cesium carbonate (0.28 g, 0.878 mmol) were heated in dry acetonitrile (4 mL, dried over 4A molecular sieves) at 160 C for one hour. The resulting was adsorbed over silica and purified by chromatography over silica gel (cyclohexane – ethyl acetate 95/5) to yield the expected compound as an oil (0.2 g, 78 %). 5H (CDCI3): 0.72 (m, 2H); 0.85 (m, 2H); 1.03 (m, 4H); 1.93 (m, 2H); 7.09 (m, 3H); 7.31 (m, 2H); 7.40 (dd, 1H, J = 2.4 and 8.5); 7.80 (d, 1 H, J – 8.5); 8.15 (d, 1H, J – 2.4); 8.27 (s, 1H). 13C (CDC13): 7.0; 7.3; 8.7; 12.6; 11 1 .0; 1 16.2; 1 17.6; 122.5; 129.6; 135.4; 136.3 ; 140.1 ; 146.0; 148.5; 149.7; 158.7. HRMS: Calc. for C20H19N3O + H: 318.1606; Found: 318.1562.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1034467-80-5, 5-Cyclopropyl-2-fluoropyridine.
Reference:
Patent; INSTITUT PASTEUR; JANIN, Yves-Louis; GUILLOU, Sandrine; LUCAS-HOURANI, Marianne; MUNIER-LEHMANN, Helene; NOEL, Anne; SALANOUVE, Elise; TANGY, Frederic; VIDALAIN, Pierre-Olivier; WO2015/155680; (2015); A2;,
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