Arshad, Zarina; Saied, Sumayya; Ali, Basharat; Salar, Uzma; Tauseef, Saima; Arshia; Ajaz, Munazza; Khan, Uroosa; Haider, Syed Moazzam; Taha, Muhammad; Khan, Khalid Mohammed published the artcile< Synthesis of N'-nicotinoyl sulfonohydrazides and their antimicrobial activity>, Formula: C7H7NO2, the main research area is nicotinoyl sulfonohydrazide preparation antibacterial antifungal.
N’-Nicotinoyl sulfonohydrazide derivatives I [R = Me, Ph, 2-O2NC6H4, etc.] were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram pos. bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram neg. bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound I [R = 2-OH-3,5-diClC6H2] showed outstanding antibacterial activity against Staphylococcus fecalis and compounds I [R = 2-O2NC6H4, 2-OH-3,5-diClC6H2] were found to be moderately activite against Salmonella Paratyphi B, shown by their zone of inhibition values. In addition to that compond I [R = Me] also showed moderate activity against Escherichia coli. All derivatives I were also subjected for the evaluation of their antifungal activity against Saccharomyces cerevisiae, Microsporum canin, Rhizopus, Aspergillus niger, Candida albicans and Candida tropicalis. Compound I [R = 2-OH-3,5-diClC6H2] showed promising antifungal activity against Rhizopus sp. and compounds I [R = Me, 2,4-di-MeOC6H3] showed moderate antifungal potential against Microsporum canis, Aspergillus niger and Candida tropicalis.
Journal of the Chemical Society of Pakistan published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.