Jiang, Xiaoli; Han, Bo; Xue, Yuhang; Duan, Mei; Gui, Zhuofan; Wang, You; Zhu, Shaolin published the artcile< Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes>, Category: pyridine-derivatives, the main research area is benzylic alkyne preparation regioselective chemoselective; alkene bromoalkyne migratory hydroalkynation nickel catalyst; chiral benzylic alkyne preparation chemoselective enantioselective; styrene bromoalkyne hydroalkynation nickel catalyst.
Here, an NiH-catalyzed reductive migratory hydroalkynation of olefins such as, 4-phenyl-1-butene, (E)-1,2-diphenylethene, 1H-indene, etc. with bromoalkynes RCCBr [R = tris(propan-2-yl)silyl, triphenylmethyl, tert-butyldiphenylsilyl] that delivers the corresponding benzylic alkynation products ArCH(CH2R1)CCR [Ar = Ph, naphthalen-2-yl, thiophen-3-yl, etc.; R1 = H, Et, 2-cyclohexylethyl, Ph, etc.] in high yields with excellent regioselectivities was reported. Catalytic enantioselective hydroalkynation of styrenes (E/Z)-Ar1CH=CHR2 [Ar1 = Ph, 2-methoxyphenyl, thiophen-3-yl, etc.; R2 = H, Me, Et, Ph, etc.] has also been realized using a simple chiral PyrOx ligand. The obtained enantioenriched benzylic alkynes (S)-Ar1CH(CH2R2)CCR [R = tris(propan-2-yl)silyl, triethylsilyl, tert-butyldimethylsilyl, etc.] are versatile synthetic intermediates and can be readily transformed into synthetically useful chiral synthons.
Nature Communications published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Category: pyridine-derivatives.